Based on the ATHENA data, a clinical utility model of the HPV primary screening algorithm was developed for the detection of cervical disease (≥CIN3) over a 3-yr follow-up period.† In women ages 25 and older, HPV primary screening with the cobas® HPV Test detected 33% more cases of ≥CIN3 than cytology with reflex HPV. Learn more below by comparing the HPV primary screening algorithm with other screening strategies.
† Model assumptions:
Based on the results from the ATHENA study, the optimal primary screening strategy focuses medical attention on women with HPV 16 and HPV 18 genotypes, and triages other high-risk genotypes, balancing detected cases and intervention.1,5 HPV DNA testing permits confident extension of screening intervals and identifies women who can return to routine screening.6
The cobas® HPV Test:
Learn more about the cobas® HPV Test.
1. Cox JT, Castle PE, Behrens CM, et al. Comparison of cervical cancer screening strategies incorporating different combinations of cytology, HPV testing and genotyping for HPV 16/18: results from the ATHENA HPV study. Am J Ob Gyn. 2012:In Press.
2. Wright TC, Stoler MH, Behrens CM, et al. The ATHENA human papillomavirus study: design, methods, and baseline results. Am J Obstet & Gynecol. 2012;206:46.e1-11.
3. Data on file, Roche Molecular Systems, Inc.
4. Herzog TJ, Monk BH. Reducing the burden of glandular carcinomas of the uterine cervix. Am J Obstet Gynecol. 2007;197:566-571.
5. Rijkaart DC, Berkhof J, Rozendaal L, et al. Human papillomavirus testing for the detection for high-grade cervical intraepithelial neoplasia and cancer: final results of the POBASCAM randomized controlled trial. Lancet Oncol. 2012; 13:78-88.
6. Katki HA, Kinney WK, Fetterman B, et al. Cervical cancer risk for women undergoing concurrent testing for human papillomavirus and cervical cytology: a population-based study in routine clinical practice. Lancet Oncol. 2011;12(7):663- 672.